The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. If youre breastfeeding, you should not receive Prolia. Healthline Media does not provide medical advice, diagnosis, or treatment. It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. With arthritis, you have pain and inflammation of your joints. You might like to know how Prolia and the drug Evenity compare. To see a side-by-side comparison of Prolia and Fosamax, view this drug article. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. No one in clinical trials of Prolia had to stop taking the drug due to dizziness. Special care may be needed. Do not shake the prefilled syringe. Prolia may lower the level of calcium in your blood. For more information about how Prolia and Zometa compare with each other, see this article. RA is an autoimmune condition in which your immune system attacks your joints. Some rare side effects of Prolia can be serious and need medical attention. Do not stop using this medicine without first talking to your doctor. Use effective birth control while using this medicine and for at least 5 months after your last dose. This could include having: Before taking Prolia, share your dental history with your doctor. Learn strategies you can use today. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Xgeva is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks. They may recommend ways to ease your symptoms and determine whether you should keep taking Prolia. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. They will also explain how much youll be given and how often. Weakness and tingling can also occur. Although its rare, your doctor may give you the option to self-inject Prolia at home. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. Lifestyle changes that can help improve cholesterol levels include exercising regularly and eating a healthy diet. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. Use of the term male in this article refers to sex assigned at birth. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. You might wonder how Prolia and the drug Xgeva compare. Your doctor will order blood tests to check your level before you start using Prolia and regularly during your treatment. But if you think youre having a medical emergency, call 911 or your local emergency number. WebIn many individuals, calcium supplements are better absorbed when taken with food. Medically reviewed by Sanjai Sinha, MD. If you dont understand something related to your condition or treatment, ask your doctor to explain it to you. Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. So, your bones become weak and brittle. NOTE: This sheet is a summary. Common side effects of this osteoporosis treatment injection include muscle, joint, and back pain. If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch. How long will the side effects of Prolia last? Learn more about some of the side effects Prolia may cause. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. And they want you to get the best care possible. Calcium and Vitamin D: A major role of vitamin D is to help the body absorb calcium and maintain bone density. Youll likely receive Prolia long term if you and your doctor decide that the drug is effective and safe for you. For more information, you can refer to the drugs prescribing information. Theyll likely suggest other treatment options for your condition. A healthcare provider will give you this injection in a hospital or clinic. WebMost people can get adequate calcium through their diet if they make an effort. Women If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. Use of the term female in this article refers to sex assigned at birth. It is important not to miss your dose. Some research has shown that alcohol consumption may increase your risk of osteoporosis, a bone fracture or impaired healing after a fracture. This drug may not be the right treatment for your condition if you have certain medical conditions or other factors that affect your health. Prolia can cause many serious side effects. Prolia should not be used during pregnancy. Talk with your doctor about which other treatments are better choices for you. if you are taking medicine that lower your blood calcium levels. What is the most important information I should know about Prolia? It is given by a health care professional in a hospital or clinic setting. Rare, long-term side effects of Prolia include fractures of the spine or femur (thighbone). pain in bones and muscles, including back, arm, and leg pain, pain or swelling in the thigh or groin area. This medicine is only given in a clinic, doctor's office, or other health care setting and will not be stored at home. Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. Its important to tell your doctor if you have serious or ongoing side effects. Low blood calcium level. Youll receive 60 mg/mL of Prolia once every 6 months. They may also have you see your dentist. But certain choices and habits accelerate the process. But if you look at D3 supplements online, youll see that most commercial supplements have higher doses usually either 1,000, 2,000, 5,000 or 10,000 IU. Common Before your appointment, write down questions, such as: How will Prolia affect my body, mood, or lifestyle? Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. For instance, if you have a health condition that causes excess calcium in Like Helpful Hug REPLY 1 reply Mamie | @mamie | Oct But hair loss has been reported by people who have taken Prolia since then. Calcium has active ingredients of calcium. This may help to protect healthy cells from damage. You should receive your missed injection as soon as possible. This is because the drug may be harmful to a growing fetus. Specifically, Prolia is a monoclonal antibody (a lab-made protein). Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. But nausea may be a symptom of side effects such as vertigo or constipation. They can help answer any questions you have about side effects from taking the drug. Your doctor can help you decide which drug is better for your needs. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. WebYou should take calcium and vitamin D as your doctor tells you to while you receive Doing so will help to prevent dental problems. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. Before starting Prolia treatment, talk with your doctor about any tooth procedures you have scheduled. This lowers your risk for bone fractures. Available for Android and iOS devices. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Copyright 2023 Elsevier Inc. All Rights Reserved. Tell your doctor if youd like to know more about these drugs. Advertising on our site helps support our mission. Patient testimonials represent individual experiences with Prolia. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. All information is observation-only. Your doctor or another healthcare professional will inject Prolia under the skin in one of the following areas: Prolia doses are given as an injection by healthcare professionals once every 6 months. Serious infections may occur during treatment with Prolia. Talk with them about your health and any concerns you have about Prolia and its effects. Its given to adults who are at high risk for bone fractures. If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. They may want to check for other causes. They may give you tips on managing a body weight thats healthy for you. But Prolia is given once every 6 months by a healthcare professional. I am taking Prolia and just saw that it's important to take Calcium because Prolia takes the calcium out of the blood and that can cause problems. You may also want to do some research on your own. 8,432 people who take Prolia and Calcium together, and have interactions are studied. Stopping some drugs leads to withdrawal symptoms because your body is used to the drug and needs it for you to feel normal. This helps treat osteoporosis by improving bone mass and strengthening your bones. Common side effects of Prolia can vary depending on which condition the drug is being used to treat. Most Medicare plans and other insurance plans cover Prolia. Learn how to increase or maintain bone density here. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. (2021). And some of these side effects are more common with certain uses of Prolia. You are encouraged to report negative side effects of prescription drugs to the FDA. In addition to treating osteoporosis, which is described just above, Prolia also has other uses. But its believed that these side effects are rare. It does the same thing that. Do not treat yourself. Use of the terms female and male in this article refers to sex assigned at birth. you can take. Before beginning treatment with Prolia, ask your doctor about the benefits and risks of the drug. For a detailed breakdown of Prolia versus Xgeva, check out this article. Please see Prolia full Both are prescription medicines. * Sex and gender exist on spectrums. Peripheral edema is a less common side effect that was reported in clinical studies of females* who received Prolia for osteoporosis after menopause. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Prolia isnt known to cause any harmful interactions with alcohol. * Symptoms can include: flushing (temporary warmth, redness, or deepening of skin color), swelling under your skin, typically in your lips, eyelids, feet, or hands, swelling of your mouth, tongue, or throat, which can make it hard to breathe. The fractures may require surgeries, take several months to heal, or both. This is called hypocalcemia. And you should continue using birth control for at least 5 months after stopping Prolia. Whats the Connection Between Estrogen and Osteoporosis? Do not use denosumab if you are pregnant. may occur. All rights reserved. For example, if you have a serious UTI or other infection, call your doctor right away. The list below may not include all possible serious side effects of the drug. The study uses data from the FDA. This makes your bones weak and increases your risk for bone fractures or breaks. In addition, your doctor will most likely recommend that you take calcium and vitamin D supplements while taking bisphosphonates, since vitamin D helps your body to absorb calcium. What do I need to be aware of if I need a tooth extraction while Im using Prolia? This is because its not known if Prolia is safe to receive while breastfeeding. Do not stop, skip or delay taking Prolia without first talking with your doctor. If you receive Prolia, you should not receive XGEVA. Will my fracture risk come back if I stop Prolia treatment? * Sex and gender exist on spectrums. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). Theyll also usually treat the hypocalcemia right away. We comply with the HONcode standard for trustworthy health information. kidney disease (or if you are on dialysis); a weak immune system (caused by disease or by using certain medicines); hypoparathyroidism (decreased functioning of the parathyroid glands); any condition that makes it hard for your body to absorb nutrients from food (malabsorption); if you are scheduled for a dental procedure; if you cannot take daily calcium and vitamin D; or. Kidney problems. Yoga is an excellent way to manage symptoms of osteoporosis. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Based on your dental history, your doctor can discuss with you the risks of using Prolia. Do any of yall know? Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of So be sure to tell your doctor about all your health conditions before taking Prolia. The drug attaches to the RANK protein and helps prevent osteoclasts from breaking down bone. If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.). Use effective birth control while using denosumab and for at least 5 months after your last dose. Tell them if you have any scheduled dental work coming up. Follow your doctor's instructions about any restrictions on food, beverages, or activity. (Hint: it's not just. (BMD is a measurement of the amount of minerals such as calcium in your bones.) If you keep this medicine at home, store it in the original carton in a refrigerator. Try to avoid being around people who are sick. Some people may have dental or jaw-related issues with Prolia use. Prolia is used in adults to treat osteoporosis or bone loss in people who: who cannot use another osteoporosis medicine or these medicines did not work well. Theyll discuss with you other treatments to help protect you from fractures and bone loss. There arent any studies that have compared these two drugs to each other. Serious side effects that have been reported and their symptoms include: * To learn more, see Does Prolia cause long-term side effects? in the FAQs about the side effects of Prolia section below. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Generic name: denosumab (Prolia) [den-OH-sue-mab] Hair loss wasnt reported as a side effect during clinical trials of Prolia. Prolia contains the active drug denosumab, and Reclast contains the active drug zoledronic acid. Get emergency medical help if you have signs of an allergic reaction to Prolia: hives, itching, rash; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat. Prolia is available as the biosimilar medication denosumab. If you develop high cholesterol with Prolia, your doctor can guide you on which treatment options are right for your condition. What Health Changes Should You Expect Postmenopause? In addition, Prolia may also be used off-label for other conditions that cause bone loss or loss of bone mineral density. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. We do not endorse non-Cleveland Clinic products or services. So, if you want to stop taking Prolia, talk with your doctor. If you develop serious side effects while taking Prolia, call your doctor right away. For example, in the studies, people taking Prolia for up to 8 years didnt have significant side effects compared with people taking a placebo. Over time, Prolia can reduce bone loss and make your bones stronger. These are not all the possible side effects of Prolia. You can learn more about how we ensure our content is accurate and current by reading our. Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. And in my mind, that's no different than scheduling a visit to the dentist twice a year. Prolia is injected under the skin. Ask your doctor about the pros and cons of using Prolia. Tell your doctor about all other medicines you use. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Prolia may cause serious side effects. Keep in mind that Prolia is used to help strengthen your bones and prevent fractures, which may happen with falls. Prolia is an injection prescribed for certain adults with osteoporosis, which This medication guide provides information about the Prolia brand of denosumab. You may wonder how Prolia compares to the medication Zometa. Having a tooth extraction while youre using Prolia may increase your risk for these side effects. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) Although both drugs are approved to treat similar conditions, they work in different ways. So, dont be afraid to ask questions or offer feedback on your treatment. Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Adults over age 50 should not exceed 2,000 mg total per day. generic drugs) are not considered. So your healthcare provider will likely ask you to take calcium and vitamin D supplements if youre not taking them already. Specifically, Prolia works by blocking a protein called RANK. Do not take this medicine with any of the following medications: This medicine may also interact with the following medications: This list may not describe all possible interactions. Some reports may have incomplete information. WebYour doctor may prescribe calcium and vitamin D to help prevent low calcium levels in Personalize this study to your gender and age, Arthrotec and Alanine Aminotransferase Increased, Capecitabine and Lumigan drug interaction, Cyramza and Gastrointestinal Stoma Necrosis, Simponi Aria and Pennsaid drug interaction, Docetaxel and Infection In An Immunocompromised Host, Ketorolac Tromethamine and Bladder Obstruction, Roxicodone and Caspofungin Acetate drug interaction, Ginkgo and Nitrofurantoin drug interaction. This information is intended only for U.S. healthcare professionals. Learn how estrogen affects bone health and how you can protect yourself from bone loss, Osteoporosis is more common in women than men, but it affects millions of men every year. With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. But if you think youre having a medical emergency, call 911 or your local emergency number. Its a, Forteos active ingredient is teriparatide. For Xgeva, talk to your pediatrician regarding the use of this medicine in children. The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. Hair loss with Prolia is rare, and whether Prolia is responsible for this effect isnt known. You should talk with your doctor if you develop any mild side effects that concern you. They have some similar uses and side effects, but they also have some differences. Youll receive Prolia doses from a healthcare professional. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. What should I know about Prolia vs. Boniva? (To learn more, see the Side effect specifics section above.). Talk with your doctor about the risks of using this drug during pregnancy. Prolia is usually given once every 6 months. As mentioned above, Prolia contains the active drug denosumab. Your doctor may suggest limiting foods that are high in trans fats, such as fried foods. WebDrug interactions are reported among people who take Prolia and Calcium. Problem absorbing minerals. Your doctor can provide more information to you about the benefits and risks of using Prolia for your condition. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. (Biologic medications are made from living organisms.). If you want to stop taking Prolia, tell your doctor. If you have osteoporosis or bone loss, your doctor may discuss Prolia as a treatment option. Store in the original container away from heat and light. But if youre planning to have surgery, you may need to take a break Another common osteoporosis medication is denosumab (Prolia, Xgeva). And some of these side effects are more common with certain uses of Prolia. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. If youre concerned about side effects with Prolia, talk with your doctor. MNT is the registered trade mark of Healthline Media. But its not clear how often this side effect occurred in clinical trials. Prolia and Forteo are both used to treat osteoporosis. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ). Cleveland Clinic is a non-profit academic medical center. Here are a few questions to consider asking your doctor: You can also learn more about osteoporosis treatment options here. And if you have osteoporosis, falling could increase your risk of fractures. More than half of American adults take an herbal or dietary supplement, and many more use over-the-counter or prescription drugs to manage maladies ranging from the occasional headache to chronic health conditions or mood disorders.. For many, it is part of their daily routine. If you have low calcium levels, you should not take Prolia. Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. Your risk of bone fractures can increase when you stop, skip or delay using Prolia. This is the drugs mechanism of action. No, Prolia isnt a bisphosphonate. WebAdults ages 19 through 50 should not get more than 2,500 mg calcium total per day (including food and supplements).
should you take calcium supplements with prolia